Check out our most up date publication list on Pubmed


25. Schmidt FI. Phenotypic Lentivirus Screens to Identify Antiviral Signle Domain Antibodies. Methods Mol Biol. 2018; 1836:139-158. PMID: 30151572

24. Ingram JR, Schmidt FI, Ploegh HL. Exploiting Nanobodies' Singular Traits. Annual Reviews of Immunology. 2018; 36:695-715. PMID: 29490163

23. Franklin BS, Latz E, Schmidt FI. The intra- and extracellular functions of ASC specks. Immunological Reviews. 2018; 281(1):74-87. PMID: 29247990


22. Schmidt FI, Latz. CD14-New Tricks of an Old Acquaintance. Immunity. 2017; 47(4):606-608. PMID: 29045891

21. Ingram JR, Blomberg OS, Sockolosky JT, Ali L, Schmidt FI, Pishesha N, Espinosa C, Dougan SK, Garcia KC, Ploegh HL, Dougan M. Localized CD47 blockade enhances immunotherapy for murine melanoma. Proceedings of the National Academy of Sciences of the United States of America. 2017; 114(38):10184-10189. PMID: 28874561

20. Schmidt FI, Ploegh HL. Editorial: Crystal death: it's not always the inflammasome... Journal of leukocyte biology. 2017; 102(1):1-4. PMID: 28667083

19. Schmidt FI. Modulation von Proteinfunktion mit Alpaka-Nanobodies in lebenden Zellen. BIOspektrum. 2017, 23(4):408-11. DOI:

18. Hanke L, Schmidt FI, Knockenhauer KE, Morin B, Whelan SP, Schwartz TU, Ploegh HL. Vesicular stomatitis virus N protein-specific single-domain antibody fragments inhibit replication. EMBO reports. 2017; 18(6):1027-1037. PMID: 28396572, PMCID: PMC5452021


17. Hanke L, Knockenhauer KE, Brewer RC, van Diest E, Schmidt FI, Schwartz TU, Ploegh HL. The Antiviral Mechanism of an Influenza A Virus Nucleoprotein-Specific Single-Domain Antibody Fragment. mBio. 2016; 7(6). PMID: 27965447, PMCID: PMC5156300

16. Schmidt FI, Hanke L, Morin B, Brewer R, Brusic V, Whelan SP, Ploegh HL. Phenotypic lentivirus screens to identify functional single domain antibodies. Nature microbiology. 2016; 1(8):16080. NIHMSID: NIHMS782622, PMID: 27573105, PMCID: PMC5010022

15. Schmidt FI*, Lu A*, Chen JW, Ruan J, Tang C, Wu H, Ploegh HL. A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly. The Journal of experimental medicine. 2016; 213(5):771-90. PMID: 27069117, PMCID: PMC4854733

14. Lu A, Li Y, Schmidt FI, Yin Q, Chen S, Fu TM, Tong AB, Ploegh HL, Mao Y, Wu H. Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism. Nature structural & molecular biology. 2016; 23(5):416-25. NIHMSID: NIHMS771531, PMID: 27043298, PMCID: PMC4856535


13. Tafesse FG, Rashidfarrokhi A, Schmidt FI, Freinkman E, Dougan S, Dougan M, Esteban A, Maruyama T, Strijbis K, Ploegh HL. Disruption of Sphingolipid Biosynthesis Blocks Phagocytosis of Candida albicans. PLoS pathogens. 2015; 11(10):e1005188. PMID: 26431038, PMCID: PMC4592247

12. Ashour J, Schmidt FI, Hanke L, Cragnolini J, Cavallari M, Altenburg A, Brewer R, Ingram J, Shoemaker C, Ploegh HL. Intracellular expression of camelid single-domain antibodies specific for influenza virus nucleoprotein uncovers distinct features of its nuclear localization. Journal of virology. 2015; 89(5):2792-800. PMID: 25540369, PMCID: PMC4325724


11. Koenig PA, Nicholls PK, Schmidt FI, Hagiwara M, Maruyama T, Frydman GH, Watson N, Page DC, Ploegh HL. The E2 ubiquitin-conjugating enzyme UBE2J1 is required for spermiogenesis in mice. The Journal of biological chemistry. 2014; 289(50):34490-502. PMID: 25320092, PMCID: PMC4263858

10. Kilcher S*, Schmidt FI*, Schneider C, Kopf M, Helenius A, Mercer J. siRNA screen of early poxvirus genes identifies the AAA+ ATPase D5 as the virus genome-uncoating factor. Cell host & microbe. 2014; 15(1):103-12. PMID: 24439902


9. Schmidt FI*, Bleck CK*, Reh L, Novy K, Wollscheid B, Helenius A, Stahlberg H, Mercer J. Vaccinia virus entry is followed by core activation and proteasome-mediated release of the immunomodulatory effector VH1 from lateral bodies. Cell reports. 2013; 4(3):464-76. PMID: 23891003

8. Schmidt FI*, Kuhn P*, Robinson T, Mercer J, Dittrich PS. Single-virus fusion experiments reveal proton influx into vaccinia virions and hemifusion lag times. Biophysical journal. 2013; 105(2):420-31. PMID: 23870263, PMCID: PMC3714929


7. Kuhn P, Eyer K, Robinson T, Schmidt FI, Mercer J, Dittrich PS. A facile protocol for the immobilisation of vesicles, virus particles, bacteria, and yeast cells. Integrative biology : quantitative biosciences from nano to macro. 2012; 4(12):1550-5. PMID: 23147942

6. Schmidt FI, Mercer J. Vaccinia virus egress: actin OUT with clathrin. Cell host & microbe. 2012; 12(3):263-5. PMID: 22980323

5. Stiefel P, Schmidt FI, Dörig P, Behr P, Zambelli T, Vorholt JA, Mercer J. Cooperative vaccinia infection demonstrated at the single-cell level using FluidFM. Nano letters. 2012; 12(8):4219-27. PMID: 22731659

4. Schmidt FI, Bleck CK, Mercer J. Poxvirus host cell entry. Current opinion in virology. 2012; 2(1):20-7. PMID: 22440962


3. Schmidt FI, Bleck CK, Helenius A, Mercer J. Vaccinia extracellular virions enter cells by macropinocytosis and acid-activated membrane rupture. The EMBO journal. 2011; 30(17):3647-61. PMID: 21792173, PMCID: PMC3181475


2. Mercer J, Knébel S, Schmidt FI, Crouse J, Burkard C, Helenius A. Vaccinia virus strains use distinct forms of macropinocytosis for host-cell entry. Proceedings of the National Academy of Sciences of the United States of America. 2010; 107(20):9346-51. PMID: 20439710, PMCID: PMC2889119


1. Hara K, Schmidt FI, Crow M, Brownlee GG. Amino acid residues in the N-terminal region of the PA subunit of influenza A virus RNA polymerase play a critical role in protein stability, endonuclease activity, cap binding, and virion RNA promoter binding. Journal of virology. 2006; 80(16):7789-98. PMID: 16873236, PMCID: PMC1563815

* contributed equally