Molecular Immunology


Florian I. Schmidt, PhD

Our Emmy Noether research group seeks to uncover how the inflammatory response against pathogens and other signatures of danger accomplishes its major goals at the molecular level: Exquisite sensitivity at maximum safety.  

We investigate how virus infection triggers the assembly of inflammasome complexes in various cell types. To delineate common strategies, we compare the responses to DNA and RNA viruses including herpesviruses (HSV-1), orthomyxoviruses (influenza A virus), poxviruses (vaccinia virus), and rhabdoviruses (vesicular stomatitis virus).

Custom-made alpaca single domain antibodies (nanobodies or VHHs) will be used to perturb, visualize and ultimately understand immunological signaling cascades in the responding cell types at endogenous protein levels.