ukb.uni-bonn.de

Publications

2019

34. Woeste, M.A., Stern, S., Raju, D.N., Grahn, E., Dittmann, D., Gutbrod, K., Dörmann, P., Hansen, J.N., Schonauer, S., Marx, C.E., Hamzeh, H., Körschen, H.G., Endepols, H., Sandhoff, R., Geyer, M., Berger, T.K., Bradke, F., Wachten, D. Species-specific differences in non-lysosomal glucosylceramidase GBA2 function underlie locomotor dysfunction arising from loss-of-function mutations. J. Biol. Chem. 2019, 294(11) 3853-71. https://doi.org/10.1074/jbc.RA118.006311

also see the cover!

33. Olstad, E.W., Ringers, C., Hansen, J. N., Wens, A., Brandt, C., Wachten, D., Yaksi, E., Jurisch-Yaksi, N. Spatially organized ciliary beating compartmentalizes cerebrospinal fluid flow in the brain and regulates ventricular development. Cur. Biol. 2019, 29 (2), 229-241; https://doi.org/10.1016/j.cub.2018.11.059

press release: https://geminiresearchnews.com/2019/01/the-most-important-hair-on-your-head-is-on-the-inside/

32. Hansen, J.N., Rassmann, S., Jikeli, J.F., Wachten, D. SpermQ - a simple analysis software to comprehensively study flagellar beating and sperm steering. Cells 2019, 8(1),10; https://doi.org/10.3390/cells801001

2018

31. Hansen, J.N., Rassmann, S., Jikeli, J.F., Wachten, D. SpermQ - a simple analysis software to comprehensively study flagellar beating and sperm steering. BioRxiv 2018https://doi.org/10.1101/449173

30. Rennhack, A., Schiffer, C., Brenker, C., Fridman, D., Nitao, E. T., Cheng, Y. M., Tamburrino, L., Balbach, M., Stolting, G., Berger, T. K., Kierzek, M., Alvarez, L., Wachten, D., Zeng, X. H., Baldi, E., Publicover, S., Kaupp, U. B. &  Strünker, T. A novel cross-species inhibitor to study the function of CatSper Ca(2+) channels in sperm. Br. J. Pharmacol. 2018, 175: 3144-61, doi: 10.1111/bph.14355

29. Smyrnias, I, Goodwin, N, Wachten, D, Skogestad, J, Aronsen, JM, Robinson, EL, Demydenko, K, Segonds-Pichon, A, Oxley, D, Sadayappan, S, Sipido, K, Bootman, MD, Roderick, HL. Contractile responses to endothelin-1 are regulated by PKC phosphorylation of cardiac myosin binding protein-C in rat ventricular myocytes. J. Mol. Cell. Cardiol., 2018, 117:1-18, doi:10.1016/j.yjmcc.2018.02.012 

28. Balbach, M, Beckert, V, Hansen JN, Wachten, D. Shedding light on the role of cAMP in mammalian sperm physiology. Mol. Cell. Endocrinol.2018, 15,486: 111-120,  PMID: 29146556

2017

27. Woeste, MA, Wachten, D. The enigmatic role of GBA2 in controlling locomotor function. Front. Mol. Neurosci., 2017, 10:386, https://doi.org/10.3389/fnmol.2017.00386

26. Farthing, NE, Findlay RC, Jikeli, JF, Bees, MA, Wilson, LG. Simultaneous two-color imaging in digital holography microscopy. Optics Exp., 2017, 23, 28489-500. https://doi.org/10.1364/OE.25.028489

25. Saggiorato, G, Alvarez, L, Jikeli, JF, Kaupp, UB, Gompper, G, Elgeti, J. Human sperm steer with second harmonics of the flagellar beat. Nat. Commun., 2017, 8, 1415. PMID: 29123094

24. Von Gerichten, J, Schlosser, K, Lamprecht, D, Morace, I, Eckhardt, M, Wachten, D, Jennemann, R, Gröne, M, Macke, M, Sandhoff, R. Diastereomer-specific quantification of bioactive hexosylceramides from bacteria and mammals. J. Lipid Res., 2017, 58, 1247–1258. PMID: 28373486

23. Körschgen, H, Kuske, M, Kramilin, K, Yiallouros, I, Balbach, M, Floehr, J, Wachten, D, Jahnen-Dechent, W, Stöcker, W. Intracellular activation of ovastacin mediates pre-fertilization hardening of the zona pellucida. Mol. Hum. Reprod., 2017, 23, 607-616. PMID: 28911209

22. Schonauer S., Körschen H.G., Penno A., Rennhack A., Breiden B., Sandhoff K., Gutbrod K., Dörmann P., Raju D.N., Haberkant P., Gerl M.J., Brügger B., Zigdon H., Vardi A., Futerman A.H., Wachten D. Identification of a feedback loop involving beta-glucosidase 2 and its product sphingosine sheds light on the molecular mechanisms in Gaucher disease J. Biol. Chem., 2017, 292(15):6177-6189. PMID: 28258214

Highlighted in FEBS Journal: Metabolic regulation of GBA2. FEBS J.2017, 284:1130.

21. Jansen V., Jikeli J.F., Wachten D. How to control cyclic nucleotide signaling by light. Curr. Opion. Biotechnol. 2017, doi: 10.1016/j.copbio.2017.02.014. PMID: 28288335

20. Berger TK, Fusshöller DM, Goodwin N, Bönigk W, Müller A, Khesroshahi ND, Brenker C, Wachten D, Krause E, Kaupp UB, Strünker T. Posttranslational cleavage of Hv1 in human sperm tunes pH- and voltage-dependent gating. J. Physiol., 2017, 595:1533-46. PMID: 27859356

19. Wachten D, Jikeli J, Kaupp UB. Sperm Sensory Signaling. Cold Spring Harb Perspect Biol, 2017doi: 10.1101/cshperspect.a028225. PMID: 28062561

 

2016

18. Schneider S, Balbach M, Jikeli J, Fietz D, Nettersheim D, Jostes S, Schmidt R, Kressin M, Bergmann M, Wachten D, Steger K, Schorle H (2016) „Re-visiting the Protamine-2 locus: deletion, but not haploinsufficiency, renders male mice infertileSci. Rep.,2016, doi: 10.1038/srep36764. PMID: 27833122

17. Mukherjee S, Jansen V, Jikeli JF, Hamzeh H, Alvarez L, Dombrowski M, Balbach M, Strünker T, Seifert R, Kaupp UB, Wachten D. A novel biosensor to study cAMP dynamics in cilia and flagella. eLife, 2016, doi: 10.7554/eLife.14052. PMID: 27003291

16. Björkgren I, Alvarez L, Blank N, Balbach M, Turunen H, Laajala TD, Toivanen J, Krutskikh A, Wahlberg N, Huhtaniemi I, Poutanen M, Wachten D, Sipilä P. Targeted inactivation of the mouse epididymal beta-defensin 41 alters sperm flagellar beat pattern and zona pellucida binding. Mol. Cell. Endocrinol.,2016, 427, 143-154. PMID: 26987518  

 

2015

15. Raju D, Schonauer S, Hamzeh H, Flynn KC, Bradke F, vom Dorp K, Dörmann P, Yildiz Y, Trötschel C, Poetsch A, Breiden B, Sandhoff K, Körschen HG, Wachten D. Accumulation of glucosylceramide in the absence of the beta-glucosidase GBA2 alters cytoskeletal dynamics. PLoS Genetics, 2015, e1005063, doi:10.1371/journal.pgen.1005063PMID: 25803043

14. Jansen V, Alvarez L, Balbach M, Strünker T, Hegemann P, Kaupp UB, Wachten D. Controlling Fertilization and cAMP signaling in sperm flagella by optogenetics. eLife, 2015, e05161. PMID: 25601414

 

2014

13. Schiffer C, Müller A, Egeberg DL, Alvarez L, Brenker C, Rehfeld A, Frederiksen H, Wäschle B, Kaupp UB, Balbach M, Wachten D, Skakkebaek NE, Almstrup K, Strünker T. Direct action of endocrine disrupting chemicals on human sperm. EMBO Rep., 2014, 15(7): p. 758-65. PMID: 24820036

12. Mass E*, Wachten D*, Aschenbrenner AC, Voelzmann A, Hoch M. Murine Creld1 controls cardiac development through activation of calcineurin/NFATc1 signaling. Dev. Cell, 2014, 28(6): p. 711-26. PMID: 24697899

 

2013

11. Krähling M, Alvarez L, Debowski K, Van Q, Gunkel M, Irsen S, Al-Amoudi A, Strünker T, Kremmer E, Krause E, Voigt I, Wörtge S, Waisman I, Weyand I, Seifert R, Kaupp UB, Wachten D. CRIS – a novel cAMP-binding protein controlling spermiogenesis and the development of the flagellar bending. PLOS Genetics, 2013, e1003960, doi: 10.1371/journal.pgen.1003960. PMID: 24339785

10. Rabionet M, Bayerle A, Marsching C, Jennemann R, Grone HJ, Yildiz Y, Wachten D, Shaw W, Shayman JA, Sandhoff R. 1-O-Acylceramides are natural components of human and mouse epidermis. J Lipid Res 2013, 54(12): p. 3312-21. PMID: 24078707

9. Körschen HG, Yildiz Y, Raju DN, Schonauer S, Böngik W, Jansen V, Kremmer E, Kaupp UB, Wachten D. The non-lysosomal beta-glucosidase GBA2 is a non-integral membrane-associated protein at the ER and Golgi. J Biol Chem 2013. 288 (5): p. 3381-93. PMID: 23250757

 

2012

8. Drawnel FM*, Wachten D*, Molkentin JD, Maillet M, Aronsen JM, Sjaastad I, Liu N, Mikoshiba K, Hisatsune C, Andrews SR, Bootman MD, Roderick HL.Mutual antagonism between IP3RII and miRNA-133a regulates cardiac hypertrophy and calcium signalling.  J Cell Biol 2012. 199 (5): p. 783-798. PMID: 23166348

 Highlighted in Journal of Cell Biology: Short B. Why a microRNA’s absence makes the heart grow larger. J Cell Biol 2012. 199 (5): p. 714.

2010

7. Smyrnias I, Mair W, Harzheim D, Walker SA, Roderick HL, Bootman MD. Comparison of the T-tubule system in adult rat ventricular and atrial myocytes, and its role in excitation-contraction coupling and inotropic stimulation. Cell Calcium 2010. 47(3): p. 210-23. PMID: 20106523

6. Harzheim D, Talasila A, Movassagh M, Foo RSY, Figg N, Bootman MD, Roderick HL. Elevated InsP3R expression underlies enhanced calcium fluxes and spontaneous extra-systolic calcium release events in hypertrophic cardiac myocytes. Channels, 2010, 4:1, 1-5. PMID: 19934645

2009

5. Harzheim D, Movassagh M, Foo RS-Y, Ritter O, Tashfeen A, Conway SJ, Bootman MD, Roderick HL. Increased InsP3Rs in the junctional sarcoplasmic reticulum augments Ca2+ transients and arrhythmias associated with cardiac hypertrophy. Proc Natl Acad Sci USA, 2009. 106(27): p. 11406-11. PMID: 19549843

2008

4.   4. Harzheim D, Pfeiffer KH, Fabritz L, Kremmer E, Buch T, Waisman A, et al. Cardiac pacemaker function of HCN4 channels in mice is confined to embryonic development and requires cyclic AMP. EMBO J,2008; 27: p. 692-703. PMID: 18219271

3. Harzheim D, Bootman MD. Physiology of HCN channels in the mammalian heart. The Bulletin of the British Society for Cardiovascular Research, 2008, 21(2): p. 4-9. 

2007

2. Bootman MD, Harzheim D, Smyrnias I, Conway SJ, Roderick HL. Temporal changes in atrial EC-coupling during prolonged stimulation with endothelin-1. Cell Calcium, 2007; 42: p. 489-501. PMID: 17574672

1. Roderick HL, Higazi DR, Smyrnias I, Fearnley C, Harzheim D, Bootman MD. Calcium in the heart: when it's good, it's very, very good, but when it's bad, it's horrid. Biochem Soc Trans, 2007; 035: p. 957-961. PMID: 17956254

* contributed equally

Books

Harzheim, D, Roderick, HL, and Bootman, MD. "Intracellular calcium signaling" In: Bradshaw, R.A., and Dennis, E.A. (eds.): Functioning of transmembrane receptors in cell signaling (Amsterdam: Academic Press), 2011, p. 377-382.

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