ukb.uni-bonn.de

Jan attended the EMBL course for RNA-sequencing analysis

08.-12.04.2019: Greetings from the European Bioinformatics Institute (EMBL-EBI) in Cambridge, UK. Supported by the BFB, Jan participated in a RNA-Sequence Analysis course at EBI. The workshops were hands-on and very helpful. Jan came home well-equipped for analyzing RNA-Sequencing data in the Wachten lab!

TRR83 - talk by Dagmar Wachten, Thomas Söllner and Ünal Coskun

Heidelberg, 11th April 2019

Together with Thomas Söllner (Heidelberg) and Ünal Coskun (Dresden), Dagmar presented the key aspects of the SFB/TRR83 at the lecture series "Überlebensstrategien", organized in Heidelberg. An interview with the Rhein-Neckar-Zeitung can be found here.

Jan gives a talk at the DPG-Frühjahrstagung

Regensburg, 3rd of April 2019: Jan presents our recently published software SpermQ at the “DPG-Frühjahrstagung” of the “Deutsche Physikalische Gesellschaft e.V.”, contributing with a short talk to the Focus session Physics of cilia (https://www.dpg-verhandlungen.de/year/2019/conference/regensburg/part/bp/session/19).

Image from colourbox.de

Cover JBC - March 15th, 2019

Poster prizes - Fabian and Olga

March, 8th, 2019

"Poster prize at the BfB meeting"

Congratulations to Olga and Fabian, who both won a poster prize at the Annual Meeting of the Bonn Network for Life Sciences (BfB)!

February, 7th, 2019

New paper in press - "GBA2 in the nervous system: lipids and gait imbalance are intertwined"

Together with Frank Bradke from the DZNE, Thomas Berger from caesar, and Matthias Geyer and Peter Dörmann from the University of Bonn, we have published a new paper in the Journal of Biochemistry. 

Here is the story:

GBA2 is a pivotal enzyme in lipid metabolism as it regulates the degradation of glucosylceramide. Glucosylceramide is a precursor lipid for other, more complex lipids, which are involved in maintaining key cellular functions. An imbalance in the glucosylceramide lipid homeostasis causes severe diseases that commonly affect the central nervous system. Mutations in the GBA2 gene have been identified in ataxic and spastic patients suffering from autosomal-recessive cerebellar ataxia (ARCA), hereditary spastic paraplegia (HSP), or the Marinesco-Sjögren-like syndrome. These patients exhibit impaired locomotion and neurological abnormalities that develop early in childhood and to date are incurable.

The group of Dagmar Wachten could show that the mutations found in patients caused a loss of GBA2 function. Thus, to study the role of GBA2 in controlling locomotion, the researchers used a mouse model that lacks GBA2 (GBA2 knockout-mice) and analyzed the gait properties compared to control mice. Indeed, GBA2 knockout-mice displayed alterations in their gait pattern and some of them displayed a strong defect in locomotion. However, the phenotype did not fully resemble the human phenotype, suggesting species-specific differences in GBA2-controlled glucosylceramide metabolism.

To study the defect on a cellular level, the morphology and function of neurons was analyzed in a petri dish. Loss of GBA2 activity had a strong defect on neuronal development and morphology, in particular on the outgrowth of cellular extensions, called neurites, which are important to transmit information in the brain from one neuron to the other. This demonstrated that the lipid homeostasis is crucial for neuronal development and sheds light on how mutations in the GBA2 gene might cause locomotor dysfunction.  

Original publication: 

http://www.jbc.org/content/early/2019/01/20/jbc.RA118.006311.abstract

 

January, 3rd, 2019

"The most important hair on your head is on the inside"

Thanks to Nathalie Jurisch-Yaksi and Emre Yaksi at the Kavli Institute in Trondheim, Norway, we could contribute to a great paper that was just published in Current Biology. 

https://doi.org/10.1016/j.cub.2018.11.059

Press release see https://geminiresearchnews.com/2019/01/the-most-important-hair-on-your-head-is-on-the-inside/

 

January, 1st, 2019

"SpermQ - a simple analysis software to comprehensively study flagellar beating and sperm steering"

Happy new year! The new year starts for us with a publication in Cells.

https://doi.org/10.3390/cells8010010

 

News feed started in 2019.

PRESS